The post Oh, Canada: The Controversy Over Neonatal Eye Ointment appeared first on Talia Zenlea.
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Local mommy groups are abuzz this week after Canadian news outlet, Global, reported that the mandatory application of prophylactic eye ointment to newborns was “ineffective, outdated and unethical.” What followed were two camps: happy hippies, and a lot of pissed off doctors. All of this suggesting to me that a lot has been misunderstood.
Here’s why this is a really big deal.
Antibiotic eye ointment is mandatory in many states and Canadian provinces. In some places, parents who refuse it on behalf of their newborns can be reported to Child Protective Services. In Texas, medical staff who fail to give it can be criminally charged for a class B misdemeanor. That sends a pretty clear message to the public and to the medical community that antibiotic eye ointment is considered REALLY IMPORTANT, and that the benefits must inarguably outweigh the risks. Unfortunately, not everyone agrees.
Now often in matters of health and wellness, we have people who disagree, even with messages as clear as this one. But this time, it’s not just anybody (cough, cough Jenny McCarthy). This time, it’s the Canadian Society for Pediatrics. In March 2015, they came out with a position statement quite clearly stating that erythromycin eye ointment should not be routinely recommended. Have the Canadians gone completely insane?
Back up. Why do we give infants eye ointment, anyway?
The reason we give infants eye ointment is to prevent something called ophthalmia neonatorum. Ophthalmia neonatorum is an eye infection that occurs in babies in their first month of life, and generally, it’s no big deal. Except for when it’s caused by an organism called N gonorrhoeae (the same bug that causes gonorrhea). In those cases, it very often progresses rapidly to a devastating eye illness and eventually blindness. The way a baby would get gonorrhea in their eye would be from passing through the birth canal of an infected mother, or even from a Cesarean delivery where the bugs crawl up the cervix into the uterus. Because a woman doesn’t always know if she is infected with N gonorrhoeae, and because it used to be pretty common, it was a no-brainer to give all babies ointment to prevent an infection that could otherwise lead to blindness.
So what’s the issue?
In the past, gonorrheal infection was a lot more common than it is now. Nowadays, the vast majority of cases of ophthalmia neonatorum (like, 99% of them) are caused by other organisms. Though erythromycin eye ointment may very well kill some of those other bugs, it’s not really necessary since those other bugs don’t cause a severe illness or blindness, the way N gonorrhoeae does.
The issue brought to light by the Canadian position statement is that it’s not really clear that erythromycin eye ointment actually works to prevent ophthalmia neonatorum caused by N gonorrhoeae, which is sort of the whole point of using it. The reason for this is that emerging strains of N gonorrhoeae are resistant (about 25%). Does overuse of erythromycin eye ointment breed this resistance? Unclear. And just to add more murk to these waters, one recent meta-analysis, which is a study that looks at the quality and findings of all the other studies on this topic, showed that the quality of all of the evidence pretty much sucked, and the prophylactic agents (like erythromycin eye ointment) had significant failure rates at preventing the disease they were being given for. So I know when I said that the vast majority of cases of ophthalmia were not caused by N gonorrhoeae anymore, many of you probably thought—well duh, that’s because we give prophylactic eye ointment now. But this argues against that—it argues that it’s not doing much at all.
But my 3 kids got erythromycin eye ointment and they’re fine.
So here is where many of the media reports missed the point. This wasn’t a discussion about the safety of erythromycin eye ointment. Some groups argue that it could blur vision and interfere with mother-baby bonding. It can also cause eye irritation in rare cases. But that wasn’t the point of the position statement. They didn’t argue that we should stop using it because it’s harmful. They argued that we should stop using it because it doesn’t work.
So why not just use it anyway? I’d take the risk of some minor eye irritation to prevent a devastating infection and blindness.
According to the Canadian Pediatrics Society (and by the way, also Denmark, Norway, Sweden and the United Kingdom, who haven’t mandated universal ocular prophylaxis in decades), there’s no reason to do something that doesn’t work. It’s like saying why not just stand on your head when you have a flat tire.
Now, the other thing they aren’t saying is that we just suck it up and deal with a small percentage of blind babies. The Canadians, like Texas, agree that gonococcal ophthalmia is really, really important. The whole point of their article was to find the best, most effective way way to prevent its devastating consequences. They went on the suggest strategies that might be better at preventing gonococcal ophthalmia, like more aggressive maternal and infant screening strategies, more aggressive medical prophylaxis for at-risk babies, early aggressive treatment when infection is identified, education, and close follow-up.
OK, so we’re good with the new plan then?
Well, not really. And this is where I think a lot of the confusion lies, and a lot of the backlash.
It’s all well and good to suggest, as the Canadian Pediatrics Society did, that we screen pregnant women for gonorrhea and treat them, and this way you’re actually preventing N gonorrhoeae from being where it shouldn’t be. The real problem is that we have no idea if this is actually an effective strategy AND it raises a whole slew of other problems.
Some people refuse testing because they don’t believe they’re at risk. But, as any doc can tell you, we’ve all seen the pregnant nun in the office, or the little old happily married lady with syphilis. Some sexual partners lie, and unfortunately, you often don’t know until something bad happens. Like your baby going blind from a gonorrheal eye infection. Also, sexually transmitted infections like gonorrhea are gifts that keep on giving. You have to treat ALL the partners. Meaning that poor pregnant lady whose partner would never cheat on her needs to be treated, but so does her husband who swears he picked it up on a public toilet seat. And probably also the women he’s adamant he’s not sleeping with.
See how this can get really tricky? So even if you manage to identify and treat the pregnant mom, you can’t control that they won’t get reinfected the next day. You know the great old wives tale of the best thing you can do to bring on labour? Well, you can even contract gonorrhea then (and no, I’m not talking about jumping up and down. Or about Flamin’ Hot Cheetos, though I’m 99% sure those worked for me.)
Did anyone ask the experts?
So, it’s cool that Global news asked a midwife what she thought. But what about the people who actually treat babies with gonococcal eye infection? Turns out, they think the Canadian Pediatrics Society’s position statement is a load of crap. The President of the Canadian Association of Pediatric Ophthalmology and Strabismus published a letter to the editor of the Canadian Journal of Ophthalmology, in which he expressed his feeling that the statement failed to recognize that gonococcal ophthalmia is a lot more common than we think because it often goes unreported, and that c trachomatis (aka chlamydia) can also cause serious problems when it finds it way into a newborn’s eye and can also be prevented with eye ointment. Additionally, it fails to consider the risks of stopping prophylactic eye ointment, and fails to present any evidence that the proposed alternatives are effective. Most importantly, it fails to adequately review the evidence. Meaning that that meta-analysis I told you about? They eye doctors interpreted the findings to say the exact opposite of what the pediatricians reported. So basically, the eye doctors think the report is a giant failure in all aspects. The author ends the letter by urging the Canadian Pediatrics Society to reconsider their position statement, and retract their recommendation to stop eye prophylaxis. Oh, and they suggested that next time the pediatricians write a position statement about eye prophylaxis, they talk it over with the eye doctors first.
Here’s the story behind the story.
What the Canadian Pediatrics Society is ACTUALLY suggesting is not to avoid the evils of Western medicine, but rather to aggressively prevent and treat infection in at-risk babies with a shot or infused antibiotics; and aggressively screen and treat pregnant moms.
As you can see, the alternative to eye ointment is fraught with a lot of potential problems, not the least of which being that the eye doctors don’t agree that it’s even necessary. I don’t know what the “right answer” is here, nor was my goal to force my opinions onto you. The purpose here was just to make sure we’re all on the same page about what the Canadians actually said. So now you know, eh?
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Social media was alive with ravenous carnivores (and smug vegetarians) after the WHO released a statement on the carcinogenic effects of red and processed meat. This prompted many news outlets to run headlines comparing red meat to cigarettes. Some serious bacon-rage ensued.
Now, before you lament your inevitable death-by-cheeseburgers, it’s important to understand what the implications of the WHO’s statement actually are.
The International Agency for Research on Cancer (known as the IARC) is an agency of the World Health Organization (WHO), tasked with evaluating all sorts of things (from smoking to microwave ovens) and determining if they cause cancer or not. They do this by evaluating the body of evidence that already exists. They then make a determination – yes, no, or maybe. Being classified as Group 1 means that something is an established carcinogen, like asbestos or cigarette smoking. Groups 2A and 2B are probably and possibly carcinogenic, respectively. Group 3 means there’s not enough data to be classified.
According to the full report, published Oct 26, 2015 in the Lancet Oncology, a working group made up of 22 scientists from all over the world convened to evaluate the carcinogenicity of red meat and processed meat. They reviewed 800 diverse studies, and based on their findings and the strength of their research methodologies, drew conclusions.
There were approximately 30 studies examining the association between red meat and colorectal cancer, and approximately 30 more pertaining to processed meat and colorectal cancer. About half of these showed a positive association.
There were also studies looking at the associations between red and processed meat and many other cancers, and positive associations were seen between consumption of red meat and cancers of the pancreas and the prostate, and between consumption of processed meat and stomach cancers.
On the basis of these findings, the IARC concluded that consumption of processed meat was “carcinogenic to humans” (Group 1) on the basis of sufficient evidence for colorectal cancer, and a positive association with the consumption of processed meat and stomach cancer.
They classified the consumption of red meat as “probably carcinogenic to humans” (Group 2A), based on the positive association between consumption of red meat and colorectal, pancreatic, and prostate cancer.
The first important point to stress is that the IARC classification is based on the strength of the evidence supporting a relationship, not the strength of the relationship. In other words, it answers the question “Is there a relationship between red and processed meat and cancer?” but does NOT answer the question “How strong is the relationship between red and processed meat and cancer?” or more importantly, “How much more likely am I to get cancer if I eat red or processed meat?” or “If I stop eating red or processed meat, how much less likely am I to get cancer?”
So when you read that processed meat has “Grade 1” status, just like cigarette smoking, arsenic or asbestos, it just means that the WHO is as confident in the relationship between processed meat and cancer as it is the relationship between cigarette smoking and cancer. NOT that processed meat is as likely to cause cancer as cigarette smoking is. And want to know what else is classified as Grade 1? Alcohol. Epstein-Barr virus (the virus that causes mono). And a bunch of life-saving medications.
I’m not trying to downplay the IARC’s findings. They are meaningful. An association was found and it wasn’t thought to be random. This means more research into this is warranted, to answer those other questions we all now have, like how risky is consuming red and processed meat? And how beneficial would it be to stop eating them? But the WHO’s statement didn’t give us much by way of guidance. They told us to eat these foods in moderation, and balance this potential risk with all the benefits of eating meat…. So, like alcohol, consume in moderation and exercise caution. And my two cents, as a gastroenterologist – if you really want to prevent colorectal cancer? Get a screening colonoscopy!
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